Role of Tyrosine Phosphorylation of HS1 in B Cell Antigen Receptor-mediated Apoptosis
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چکیده
منابع مشابه
Role of Tyrosine Phosphorylation of HS1 in B Cell Antigen Receptor-mediated Apoptosis
The 75-kD HS1 protein is highly tyrosine-phosphorylated during B cell antigen receptor (BCR)-mediated signaling. Owing to low expression of HS1, WEHI-231-derived M1 cells, unlike the parental cells, are insensitive to BCR-mediated apoptosis. Here, we show that BCR-associated tyrosine kinases Lyn and Syk synergistically phosphorylate HS1, and that Tyr-378 and Tyr-397 of HS1 are the critical resi...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1997
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.185.7.1387